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Activation of Akt pathway (PKB/Akt/PI 3 ) is correlated with neuroprotection since Akt pathway stimulates the expression of many neuroprotective factors such as: estrogens, brain-derived neurotrophic factor (Marchetti et al., 2004

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The disappointing results of targeting NMDARs with indirect receptor agonists may be attributed to the lack of a clear understanding of the neuronal and circuitry mechanisms involved in the dysfunction of the glutamine system in SZ 8